The collection is of great importance not only for the high quality of the works, but also for their close link with the history of Montepulciano: the visitors can find here, in fact, two altarpieces Dio Padre Beneficente (Heavenly Father the Beneficent), formerly in the Palazzo Comunale, and the lunette depicting Madonna con Bambino (Madonna with Child), formerly in the Palazzo del Capitano, commissioned to Andrea della Robbia from 1484 to the beginning of 1525. Another notable work is the altarpiece fragment with San Giovanni Battista (Saint John the Baptist) probably coming from the destroyed convent of Fontecastello.